Stichting NoSelf Foundation proliferates the beneficial use of “cell-free nucleic acid based” technologies into the developing world. First in Eastern Africa, using spirulina as an ancient carrier of many health inducing effects, for plants and human/animals. (Including the species-specific inhibitory and repellent effects on pests, plagues and pathogens -see patents below). We focus our efforts mainly on Leishmania and Malaria solutions as well as the Helicobacter pylori and Soil Transmitted Helminth infections, using a string of peer-reviewed NoSelf scientific publications that started in 2014. (Abstract below).

Biomimetic applications of non-self nucleic acids are microbiome modulation (humans-), gut flora stabilizers (livestock-) and biostimulants (crops). Biomimetic applications of self nucleic acids are novel antibiotics and the suppression of weeds, nematodes, fungi, insects, bacteria with their own extracellular, randomly fragmented or secreted selfDNA.

Patent 1: The use of randomly fragmented genomic DNA. Patent 2: The use of secreted DNA for specific inhibition. Agricultural animation: 3 Minutes watching time, and worth it.

Commercial companies connected to us are AND Biotech AG, Basel, Switzerland and AND Biologicals BV, Rotterdam, the Netherlands. We originated out of No Self SRL, Italy, a groundbreaking multi-disciplined, international, research and development organisation, led by Professor Dr. Stefano Mazzoleni, University of Napoli, Federico II.

Noself Foundation “democratizes” both the crop protection industry and the pharma industry by demonstrating that evidence based, scientifically evaluated, natural solutions can help the developing world free itself from the burden of large and longterm R&D budgetary requirements with local solutions for local problems by local entities, quicker than usual. True to As Nature Does and within the One Health paradigm. Want to know more? Get in touch through as-nature-does@noself.foundation

Abstract

The research for new products against pathogens, parasites and infesting species, in both agriculture and medicine, implies huge and increasing scientific, industrial and economic efforts. Traditional approaches are based on random screening procedures searching for bioactive compounds. However, the success of such methodologies in most cases has been strongly limited by side-effects of the potential new drugs, especially toxicity and pharmacological resistance. The use of nucleic acids in drug development has been introduced searching for target-specific effect. In addition, a recent discovery revealed that randomly fragmented extracellular self-DNA may act as highly species-specific inhibitory product for different species, suggesting an unprecedented use of nucleic acids for biological control. On this base, a new scenario of pharmacological applications is discussed.