Stichting NoSelf Foundation proliferates the beneficial use of “cell-free nucleic acid based” technologies into the developing world. First in Eastern Africa, using spirulina as an ancient carrier of many health inducing effects, for plants and human/animals. (Including the species-specific inhibitory and repellent effects on pests, plagues and pathogens -see patents below). Next to agricultural solutions we focus our efforts mainly on Helicobacter pylori reduction, using a string of peer-reviewed NoSelf scientific publications that started in 2014. (Abstract below).

Applications of non-self/self nucleic acids are microbiome modulation (humans-), gut flora stabilizers (livestock-) and biostimulants (crops). These biomimetic uses of cell-free nucleic acids lead to novel antibiotics as well as to the suppression of weeds, nematodes, fungi, insects, bacteria with their own extracellular, randomly fragmented or secreted selfDNA. For farmers and growers we promote Diversity as a Service; restoring cell-free nucleic acid diversity within the almost sterile monocultures of high- and mid-tech horticulture, neutralizing autotoxicity in such vulnerable cultures and reducing all kinds of growers’ troubles. Diversity as a Service also enables farmers and growers to produce on-farm, for-farm and by-farm their biocontrol and biostimulant systems, improving their resilience.

Background IP: Patent 1: The use of randomly fragmented genomic DNA. Patent 2: The use of secreted DNA for specific inhibition. Patent 3 (pending-): Use of nucleic acids as fertilizers and stimulants. Patent 4 (pending-): Mixing of dna molecules, uses thereof as biological inhibitor and method for production. Agricultural animation: 4 Minutes watching time, and worth it!

Commercial companies connected to us are AND Biotech AG, Basel, Switzerland, Algaementum, Portugal and AND Biologicals BV, Rotterdam, the Netherlands. We originated out of No Self SRL, Italy, a groundbreaking multi-disciplined, international, research and development organisation, led by Professor Dr. Stefano Mazzoleni, University of Napoli, Federico II.

Noself Foundation “democratizes” both the crop protection practices and the pharma industry by demonstrating that evidence based, scientifically evaluated, natural solutions can help the developing world free itself from the burden of large and longterm R&D budgetary requirements with local solutions for local problems by local entities, quicker than usual. True to As Nature Does and within the One Health paradigm. Want to know more? Get in touch with NoSelf Foundation and/or its subsidiary PuraNatura International BV through pj at peter-jens dot eu, Chamber of Commerce, the Netherlands: 27303107 0000, address Arent Dirckszn Vosstraat 15, 2678CP De Lier, the Netherlands.

Abstract

The research for new products against pathogens, parasites and infesting species, in both agriculture and medicine, implies huge and increasing scientific, industrial and economic efforts. Traditional approaches are based on random screening procedures searching for bioactive compounds. However, the success of such methodologies in most cases has been strongly limited by side-effects of the potential new drugs, especially toxicity and pharmacological resistance. The use of nucleic acids in drug development has been introduced searching for target-specific effect. In addition, a recent discovery revealed that randomly fragmented extracellular self-DNA may act as highly species-specific inhibitory product for different species, suggesting an unprecedented use of nucleic acids for biological control. On this base, a new scenario of pharmacological and biocontrol applications is discussed.